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KMID : 1098420190270030194
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Korean Journal of Medicinal Crop Science
2019 Volume.27 No. 3 p.194 ~ p.201
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Comparison of Anti-oxidant and Anti-inflammatory Activities of Methanolic Extracts Obtained from Different Parts of Cotoneaster wilsonii Nakai
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Yoo Nam-Ho
Kim Hee-Kyu
Lee Chan-Ok
Park Ju-Hee f
Kim Myong-Jo
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Abstract
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Background: The Ministry of Environment, Korea recognizes Cotoneaster wilsonii Nakai as a second-class endangered plant. It is a native species that grows in Ulleung-do, Korea. To our knowledge, the bioactivity of this plant has not yet been reported. Therefore, in this study, we have reported the bioactivity of C. wilsonii Nakai.
Methods and Results: The anti-oxidant activities of C. wilsonii methanolic extract were investigated in vitro. The anti-oxidant activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, and the total phenolic and flavonoid content were measured. The leaf methanolic extract had the highest DPPH radical scavenging activity (IC50; 15.74 ㎍/㎖), and it also had the highest total phenolic and flavonoid content (220.95 ㎎·GAE/g, and 36.46 ㎎·QE/g extract respectively). Through high performance liquid chromatography (HPLC) analysis, chlorogenic acid was found to be the predominant among all phenolic compounds, showing a concentration of 84.24 ㎎/g extract. More than 60% decrease in nitric oxide (NO) production was found in the leaf methanolic extract.
Conclusions: To the best of our knowldege, this is the first report of the bioactivities of C. wilsonii. The results demonstrate that the leaf methanolic extract of C. wilsonii shows potent anti-oxidant, and anti-inflammatory activities.
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KEYWORD
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Cotoneaster wilsonii Nakai, Anti-oxidant, Anti-inflammatory, Caffeic Acid, Chlorogenic acid, Ferulic Acid, Gallic Acid, High Performance Liquid Chromatography, Syringic Acid
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